The place: Theah. The time: 1666. The White Plague ravages the land, towns barricade themselves in quarantine and ruthlessly purge any signs of contamination from within. But there are rumors of a cure, a Syrneth mystery, hidden in a Numan ruin. Alas, the powers of Vodacce are not keen on outsiders at the best of times, and now they've become downright unpleasant about them. Can a band of certified Explorers discover the solution to the mysterious plague and stay alive? Odds are pretty good; this is 7th Sea, not Call of Cthulhu.
(As may be obvious by all the jargon, players who have a familiarity with the 7th Sea world may find this easier than those without, but I will bring you up to speed if need be.)